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Kerry bardy diagnostics12/7/2023 ![]() ![]() Sample sizes were limited among patients aged ≥75 years. ![]() In unadjusted exploratory analyses, ICD recipients were less likely to die than nonrecipients in all age groups: among patients aged <55 years: hazard ratio 0.48, 95% posterior credible interval 0.33 to 0.69 among patients aged 55 to 64 years: hazard ratio 0.69, 95% posterior credible interval 0.53 to 0.90 among patients aged 65 to 74 years: hazard ratio 0.67, 95% posterior credible interval, 0.53 to 0.85 and among patients aged ≥75 years: hazard ratio 0.54, 95% posterior credible interval 0.37 to 0.78. Compared with their younger counterparts, older patients had a greater burden of comorbid illness. Median age at enrollment was 62 (interquartile range 53-70) years. The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain.ĭata from 5 major ICD trials were merged: the Multicenter Automatic Defibrillator Implantation Trial I (MADIT-I), the Multicenter UnSustained Tachycardia Trial (MUSTT), the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II), the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Trial (DEFINITE), and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Policlinico San Donato, Milan, Italy (R.C.) University of Toronto, Ontario, Canada (P.D.) Northwestern Feinberg School of Medicine, Chicago, IL (A.H.K.) and University of Rochester, Rochester, NY (A.J.M.). 2 From the Duke Clinical Research Institute, Durham, NC (P.L.H., S.M.A., R.E., K.L.L., D.B.M., G.S.) University of Washington, Seattle (J.Y.H., G.H.B., A.H., P.J.K., L.Y.T.I.) Columbia University, New York, NY (J.T.B., R.S.) Beth Israel Deaconess Medical Center, Boston, MA (A.B.) I.R.C.C.S. 1 From the Duke Clinical Research Institute, Durham, NC (P.L.H., S.M.A., R.E., K.L.L., D.B.M., G.S.) University of Washington, Seattle (J.Y.H., G.H.B., A.H., P.J.K., L.Y.T.I.) Columbia University, New York, NY (J.T.B., R.S.) Beth Israel Deaconess Medical Center, Boston, MA (A.B.) I.R.C.C.S. ![]()
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